The scientific research project, "Measurement of porin-based antibiotic permeability using high-resolution terahertz time-domain spectroscopy," led by Associate Professor Fatma Doğan Güzel of the Faculty of Engineering and Natural Sciences, Department of Mechanical Engineering, has been awarded funding by the Scientific and Technological Research Council of Turkey (TÜBİTAK) under the 2515-COST European Cooperation in Science and Technology Program.
The project aims to develop a new terahertz time-domain spectroscopy-based measurement platform for the study of antibiotic permeation pathways (porins) in Gram-negative bacteria. This fluorescence-free, rapid, and highly sensitive method is expected to contribute to a better understanding of antibiotic resistance mechanisms and to reduce unnecessary antibiotic use. The project, with a budget of approximately 2.4 million TL, is funded by TÜBİTAK under the "European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP)-CA21145" action of the "2515-COST Programme for European Cooperation in Science and Technology."
Researchers involved in the project:
• Dr. Aliakbar Ebrahimi (AYBU, Biomedical Engineering, Postdoctoral Researcher)
• Prof. Dr. Cihan Darcan and Lecturer Dr. Özge Kaygusuz İzgördü (Bilecik Şeyh Edebali University, Molecular Biology and Genetics)
• Assoc. Prof. Dr. Kholoud Elmabruk (Sivas University of Science and Technology, Electrical and Electronics Engineering)
Project advisors:
• Prof. Dr. Asaf Behzat Şahın (AYBU, Electrical and Electronics Engineering)
• Prof. Dr. Hakan Altan (Middle East Technical University, Physics)
This study, which will be conducted through the synergy of engineering, biophysics, and microbiology, aims to develop innovative solutions to the problem of antibiotic resistance using next-generation microfluidic and analytical platforms. The results are expected to significantly contribute to our country's scientific research capacity and international competitiveness in drug discovery and diagnostic technologies.
We congratulate our faculty member and his research team and wish them continued success.
